#4074 FRACTIONATED PLASMA SEPARATION AND ADSORPTION INTEGRATED WITH CONTINUOUS VENO-VENOUS HEMOFILTRATION IN PATIENTS WITH ACUTE LIVER FAILURE

Abstract Background and Aims To observe the clinical efficacy safety of fractionated plasma separation adsorption integrated with continuous veno-venous hemofiltration (FPSA-CVVH) treatment in patients acute liver failure (ALF). Method In this retrospective study, we enrolled ALF (serum total bilirubin>10mg/dl or Model for End-Stage Liver Disease (MELD) Score>18) hospitalized from 2017 to 2022.All received FPSA-CVVH.The primary measure was reduction ratios (RRs) bilirubin after each session FPSA-CVVH. Results 8 (68 males 10 females) were enrolled. 66 (84.6%) exhibited kidney injury required renal replacement therapy (RRT). The score MELD at baseline 22.9±7.5. concentration serum 22.05±5.94mg/dL, direct 16.33±4.60mg/dL indirect 3.43±1.60mg/dL.187 sessions FPSA-CVVH hours performed. After a single session, bilirubin, significantly decreased. RRs 52.0±7.6% 59.4±13.0% 36.9±15.4% bilirubin. 2 changed filters due blood coagulation. And other bleeding, including gastrointestinal bleeding Oozing bleeding. 29 (37.2%) survived discharging hospital, 12 recovered their function, remaining 17 still needed intermittent artificial support therapy. Conclusion novol effective ALF. It may be considered as “bridge technique” recovery function critical ill